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Ebola

Congo RiverPublications

Ebola relapse study out in NEJM

Our study investigating a rare case of Ebola relapse has been published in the New England Journal of Medicine. Together with our colleagues at INDR in the Democratic Republic of Congo, the University of Nebraska Medical Center in Omaha, and several other institutions, we investigated a case of a vaccinated man who had already been sick with Ebola fell ill with…
April 9, 2021
creidPress Releases

New NIAID-funded center established

The ongoing COVID-19 pandemic has exposed the urgent need to protect the world from microbial threats, whenever and wherever they emerge. With a new $8.9 million grant, our lab is partnering with peers in the United States and West Africa, a region of the world where infectious diseases are a high burden on public health. (more…)
August 27, 2020
Cell abstractPublications

Ebola antibody research

In two papers published in Cell and Cell Host Microbe together with our collaborators at VIC, CViSB, and VHFC we describe in detail antibody responses to Ebola virus. By systematic analysis of a large set of more than 170 monoclonal antibodies to Ebola virus, we investigated which immunological features play key roles in protection against the virus. This was our first…
August 10, 2018
cvisbPress Releases

CViSB established

Scripps Research scientists receive $15 million to study viral outbreak survivors. With a new $15 million grant, scientists at Scripps Research are gearing up for an in-depth study of survivors of viral outbreaks. The grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases will support the efforts of the Scripps Research-led Center for Viral Systems…
February 15, 2018
Cell abstractPublications

Ebola paper in Cell

In a recent study published in Cell together with colleagues from UMass Worcester and the Broad, we show how a single mutation that occurred during the 2013-2016 Ebola virus disease epidemic in West Africa increased the ability of the virus to infect human cells. The mutation occurred in the Ebola virus glycoprotein and is located in the receptor binding domain of…
November 22, 2016
Nature paperPublications

Review on Ebola evolution in Nature

The 2013-2016 Ebola epidemic in West Africa was of unprecedented size and devastation, but also stands a landmark for infectious disease genomics. By sequencing virus genomes directly from patient samples, scientists are now able to investigate how viruses evolve, transmit between individuals, and spread across country borders during outbreaks, directly informing infection control. (more…)
October 12, 2016
ratesPublications

Flawed Ebola study in Science

In a technical comment in Science, we show how a study published in 2015 by Hoenen, Feldmann, and others was based on faulty analyzes and a misunderstanding of the findings. The original article by the authors, as well as a later published erratum, failed to account for significant data analysis errors performed by Hoenen and colleagues.  (more…)
August 12, 2016
Publications

Roots, Not Parachutes

Infectious disease outbreaks continue to pose challenges to global health and security, prompting reactive countermeasures. Recently, severe outbreaks of Ebola and Zika virus were designated by the World Health Organization as “Public Health Emergencies of International Concern.” Other emerging viral pathogens have warranted similar attention, including virus outbreaks from Lassa, Chikungunya, avian influenza, Nipah, SARS, and MERS. (more…)
June 30, 2016
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