Andersen Lab

We are using infectious disease genomics to investigate how highly pathogenic viruses such as Zika, Ebola, and Lassa emerge and cause large-scale outbreaks. Using a combination of computational biology, experimentation, and field work, our hope is to transform outbreak response and change the way we develop vaccines and therapeutics.

Launch of CViSB U19 Center

cvisb_centerWith a $15 million U19 center grant from the NIH National Institute of Allergy and Infectious Diseases, we are excited to announce that we have established the Center for Viral Systems Biology (CViSB; https://cvisb.org). This highly collaborative work spans scientific boundaries and our mission is to use high-throughput experimental and computational approaches to elucidate how some people are able to survive Ebola and Lassa virus infections. Kristian will serve as the principal investigator of the center, and together with Bob Garry from Tulane University, will be the co-director of CViSB. The center is a large-scale international collaboration between Scripps Research, Kenema Government Hospital, Tulane University, UCLA, Harvard, and MIT.

The establishment of the CViSB center will allow our lab to expand into new exciting scientific avenues. Utilizing the technological, biological, and computational resources we have generated over the last couple of years, we will be able to turn our focus to understanding disease in individual patients, in addition to our prior work elucidating the forces driving outbreaks. We are very excited about this new work, and we invite talented candidates to apply for some of the many jobs the creation of this center has allowed. Please have a look at the jobs section of our website, or check out the jobs section on the CViSB website.

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Partners

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News

News

CViSB workshop

Together with Marc Suchard from UCLA, we’re pleased to host the upcoming CViSB “Systems Biology of Infectious Disease” workshop February 20-22, 2019 in La Jolla, CA. Those wanting to learn more about genomics and phylogenetic methods to analyze infectious diseases will not want to miss it! (more…)
Publications

Ebola antibody research

In two papers published in Cell and Cell Host Microbe together with our collaborators at VIC, CViSB, and VHFC we describe in detail antibody responses to Ebola virus. By systematic analysis of a large set of more than 170 monoclonal antibodies to Ebola virus, we investigated which immunological features play key roles in protection against the virus. This was our first…
Data

Hidden Zika outbreak

Summary: Using local and travel-associated case reporting from American and European public health systems, we identified an unreported Zika outbreak in Cuba during 2017. Virus sequencing from travelers revealed that the Zika outbreak in Cuba was sparked by multiple introductions of the virus from elsewhere in the Caribbean and Central America during 2016 that persisted into 2017. The recent Zika virus…