Andersen Lab

We are using infectious disease genomics to investigate how highly pathogenic viruses such as Zika, Ebola, and Lassa emerge and cause large-scale outbreaks. Using a combination of computational biology, experimentation, and field work, our hope is to transform outbreak response and change the way we develop vaccines and therapeutics.

Launch of CViSB U19 Center

cvisb_centerWith a $15 million U19 center grant from the NIH National Institute of Allergy and Infectious Diseases, we are excited to announce that we have established the Center for Viral Systems Biology (CViSB; https://cvisb.org). This highly collaborative work spans scientific boundaries and our mission is to use high-throughput experimental and computational approaches to elucidate how some people are able to survive Ebola and Lassa virus infections. Kristian will serve as the principal investigator of the center, and together with Bob Garry from Tulane University, will be the co-director of CViSB. The center is a large-scale international collaboration between The Scripps Research Institute, Kenema Government Hospital, Tulane University, UCLA, Harvard, and MIT.

The establishment of the CViSB center will allow our lab to expand into new exciting scientific avenues. Utilizing the technological, biological, and computational resources we have generated over the last couple of years, we will be able to turn our focus to understanding disease in individual patients, in addition to our prior work elucidating the forces driving outbreaks. We are very excited about this new work, and we invite talented candidates to apply for some of the many jobs the creation of this center has allowed. Please have a look at the jobs section of our website, or check out the jobs section on the CViSB website.

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News

Publications

Malaria paper in Cell

Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xerocytosis are associated with gain-of-function mutations in PIEZO1, a mechanically activated ion channel. We…
Publications

Zika genomics commentary in Cell

The emergence and spread of Zika virus in the Americas continues to challenge our disease surveillance systems. Virus genome sequencing during the epidemic uncovered the timescale of Zika virus transmission and spread. Yet, we are only beginning to explore how genomics can enhance our responses to emerging viruses. Together with our colleagues Nuno Faria and Oliver Pybus at the University…
Press Releases

CViSB established

TSRI scientists receive $15 million to study viral outbreak survivors. With a new $15 million grant, scientists at The Scripps Research Institute (TSRI) are gearing up for an in-depth study of survivors of viral outbreaks. The grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases will support the efforts of the TSRI-led Center for Viral…