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Congo RiverPublications

Ebola relapse study out in NEJM

Our study investigating a rare case of Ebola relapse has been published in the New England Journal of Medicine. Together with our colleagues at INDR in the Democratic Republic of Congo, the University of Nebraska Medical Center in Omaha, and several other institutions, we investigated a case of a vaccinated man who had already been sick with Ebola fell ill with…
April 9, 2021
graphical abstractPublications

Study on B.1.1.7 out in Cell

Our study investigating the spread of the B.1.1.7 SARS-CoV-2 variant first discovered in the UK has been published in the journal Cell. Together with our colleagues at the San Diego-based company Helix, we used testing data, genomics, and modeling to answer two simple questions - when was B.1.1.7 introduced into the US and how is it currently spreading in this country?…
April 9, 2021
Cell abstractPublications

Zika surveillance study in Cell

Our study investigating smoldering 'hidden' outbreaks of Zika in the Americas was published on the cover of Cell. In this paper we used travel surveillance and genomic epidemiology to answer a simple question - "in 2017, was the epidemic over?". The short answer, is no - read the rest of the study for the long answer. The Zika epidemic in…
August 23, 2019
Cell abstractPublications

Ebola antibody research

In two papers published in Cell and Cell Host Microbe together with our collaborators at VIC, CViSB, and VHFC we describe in detail antibody responses to Ebola virus. By systematic analysis of a large set of more than 170 monoclonal antibodies to Ebola virus, we investigated which immunological features play key roles in protection against the virus. This was our first…
August 10, 2018
holmes nature commentaryPublications

Pandemics: Focus on surveillance

Over the past 15 years, outbreaks caused by viruses such as Ebola, SARS, and Zika have cost governments billions of US dollars. Combined with a perception among scientists, health workers and citizens that responses to outbreaks have been inadequate, this has fueled what seems like a compelling idea. Namely, that if researchers can identify the next pandemic virus before the…
June 11, 2018
Cell abstractPublications

Malaria paper in Cell

Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xerocytosis are associated with gain-of-function mutations in PIEZO1, a mechanically activated ion channel. We…
April 12, 2018
Cell abstractPublications

Zika genomics commentary in Cell

The emergence and spread of Zika virus in the Americas continues to challenge our disease surveillance systems. Virus genome sequencing during the epidemic uncovered the timescale of Zika virus transmission and spread. Yet, we are only beginning to explore how genomics can enhance our responses to emerging viruses. Together with our colleagues Nuno Faria and Oliver Pybus at the University…
March 12, 2018

Zika papers in Nature

In a series of papers in the journals Nature and Nature Protocols, we used Zika virus sequencing from patients and mosquitos to show how the virus has spread across South America and into Florida. This work was performed as a large (huge!) collaboration of national and international institutions, which was made possible because of open science and open data. (more…)
May 25, 2017